The first step is asking for ANA followed by b ,positive antinuclear antibody: referred to as ANA and present in nearly all patients with lupus.Certain antibodies that show an immune system problem: anti-double-strand DNA (called anti-dsDNA), anti-Smith (referred to as anti-Sm) or antiphospholipid antibodies, or a false-positive blood test for syphilis (meaning you do not really have this infection)
So first choice is A